1. What is Non-LDL-C?

Non-LDL-C represents all cholesterol that is not low-density lipoprotein. It includes HDL, VLDL, and other atherogenic lipoproteins. High levels (>130 mg/dL) are associated with increased cardiovascular risk.

2. How Does the Calculator Work?

The calculator uses the Non-LDL-C formula:

Where:

• Total Cholesterol — The sum of all cholesterol in blood
• LDL — Low-density lipoprotein cholesterol

Explanation: This calculation provides an estimate of all non-LDL cholesterol particles, which are considered atherogenic and contribute to cardiovascular disease risk.

3. Importance of Non-LDL-C Calculation

Details: Non-LDL-C is a valuable secondary target for cholesterol management, especially when LDL measurement is unavailable or when triglycerides are elevated. Levels above 130 mg/dL are considered high and may require intervention.

4. Using the Calculator

Tips: Enter total cholesterol and LDL values in mg/dL. Both values must be valid positive numbers, and LDL should not exceed total cholesterol.

5. Frequently Asked Questions (FAQ)

Q1: Why is non-LDL-C important?
A: Non-LDL-C includes all atherogenic cholesterol particles and may be a better predictor of cardiovascular risk than LDL alone, especially in people with high triglycerides.

Q2: What are optimal non-LDL-C levels?
A: Optimal is generally <130 mg/dL. Levels between 130-159 mg/dL are borderline high, 160-189 mg/dL are high, and ≥190 mg/dL are very high.

Q3: When should non-LDL-C be calculated?
A: It's particularly useful when triglycerides are elevated (>200 mg/dL) or when LDL measurement is not available.

Q4: How does non-LDL-C relate to other lipid parameters?
A: Non-LDL-C correlates well with apolipoprotein B levels and provides a comprehensive measure of atherogenic cholesterol particles.

Q5: Should non-LDL-C be used for treatment decisions?
A: Yes, many guidelines recommend non-LDL-C as a secondary treatment target, especially in high-risk patients or those with hypertriglyceridemia.